How do i contact the ipledge program? For iPLEDGE Program Information Call Center hours: Monday through Saturday, 9AM–12AM (midnight) EST 1-866-495-0654 www.ipledgeprogram.com 1 Reference ID: 3136456How many phone numbers does ipledge have? In total, iPledge has 1 phone number. It's not always clear what is the best way to talk to iPledge representatives, so we started compiling this information built from suggestions from the customer community. Please keep sharing your experiences so we can continue to improve this free resource.Do female patients need to enroll in ipledge? Female patients are also required to take pregnancy tests before, during, and after treatment. Both male and female patients will need to enroll in iPLEDGE ® and follow the requirements of the program.What is the ipledge program for accutane? iPLEDGE program. The iPLEDGE program is a mandatory distribution program in the United States for isotretinoin (sold under the trade name Accutane, among others). It is intended to prevent the use of the medication during pregnancy due to the high risk of birth defects ( see Teratogenicity of isoretinoin ).